Bispecific T cell Engager 

Creative Biolabs
45-1 Ramsey Road
Shirley, NY 11967
United States


With the most advanced technology and years of experiences in antibody engineering field, Creative Biolabs now provide custom construction and production services for Bi-specific T-cell engagers (BiTEs). BiTE antibodies are recombinant fusion proteins consisting of two single-chain variable fragments (scFvs) of different antibodies. One of the scFvs binds to T cells via the CD3 receptor, and the other to a tumor cell via a tumor specific molecule. BiTEs are a very important class of artificial bi-specific monoclonal antibodies that are investigated for the use as anti-cancer drugs. By employing variable domains with binding specificities against different surface antigens of malignant cells and linking them to a CD3-binding domain, BiTEs can potentially be engineered to target a wide range of tumors.
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